Protective role of antioxidant vitamin E and catechin on idarubicin-induced cardiotoxicity in rats

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چکیده

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Protective role of antioxidant vitamin E and catechin on idarubicin-induced cardiotoxicity in rats.

Idarubicin is an anthracycline antibiotic extensively used in acute leukemia. In the present study we investigated whether vitamin E and catechin can reduce the toxic effects of idarubicin. Vitamin E (200 IU kg(-1) week(-1)), catechin (200 mg kg(-1) week(-1)), idarubicin (5 mg kg(-1) week(-1)), idarubicin + vitamin E (200 IU kg(-1) week(-1)), and idarubicin + catechin (200 mg kg(-1) week(-1)) c...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2002

ISSN: 0100-879X

DOI: 10.1590/s0100-879x2002001100017